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Mourot, J

discovered that downregulation of mTOR in LN patients leads to a reduction in STAT3 and Th17 cells within effector T cells, while inhibiting the AKT signaling pathway hinders the migration of Th17 cells towards inflammatory sites, effectively mitigating the chronic inflammatory process in LN (38, 156)

The perspective outlined here emphasizes regenerative capacity relative to metabolic flux rather than absolute accumulation of reactive oxygen species

If you just keep pouring more and more fuel (NAD+) into the car (your body), it may initially seem like youre making the engine run better, but if you don't pay attention to the oil and spark plugs (other necessary systems), the car might start having problems